マズロペプチン
Multi tool use(−)-マズロペプチン発色団メタノール付加体
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IUPAC名 (7R,14R,15S,16R,22R)-7,16-ジヒドロキシ-11,22-ジメトキシ-15-[[3α,4α-ジヒドロキシ-4-メチル-5α-[(2-ヒドロキシ-3,6-ジメチルベンゾイル)アミノ]テトラヒドロ-2H-ピラン-2β-イル]オキシ]-25-クロロ-4-アザ-13-オキサテトラシクロ[12.7.3.18,12.015,19]ペンタコサン-1,8(25),9,11,18-ペンタエン-20,23-ジイン-5-オン
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識別情報
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PubChem
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44249557
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特性
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化学式
| C40H43ClN2O12 |
モル質量
| 779.23 g mol−1 |
特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。
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マズロペプチン (maduropeptin) は、Actinomadura maduraeから単離された色素タンパク質（英語版）であり、タンパク質 (MdpA) と発色団（英語版）（クロモフォア）の1対1の混合物から成る[1]。発色団は不安定であり付加体のみが単離できる[2]。発色団はエンジイン構造を持つ抗生物質であり、抗がん活性も示す。
脚注
^ Hanada M, Ohkuma H, Yonemoto T, Tomita K, Ohbayashi M, Kamei H, Miyaki T, Konishi M, Kawaguchi H, Forenza S (1991). “Maduropeptin, a complex of new macromolecular antitumor antibiotics”. J. Antibiot. (Tokyo) 44 (4): 403-414. doi:10.7164/antibiotics.44.403. PMID 2032949.
^ Komano K, Shimamura S, Norizuki Y, Zhao D, Kabuto C, Sato I, Hirama M (2009). “Total synthesis and structure revision of the (−)-maduropeptin chromophore”. J. Am. Chem. Soc. 131 (34): 12072-12073. doi:10.1021/ja905397p. PMID 19655742.
外部リンク
- Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate
 | この項目は、化学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:化学／Portal:化学）。 |
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