With server.py running:

from flask import Flask, request, Response

app = Flask(__name__)

@app.route('/test', methods=['GET','POST'])
def route(): 
 print('got files: %s' % request.files)
 return Response()

if __name__ == '__main__':
 app.run('0.0.0.0', 5000)

send a request using client.py:

import json, requests 

dictionary_1 = "file": "url": "https://bootstrap.pypa.io/get-pip.py" 

files = [('dictionary_1', ('get-pip.py', json.dumps(dictionary_1), 'application/json'))]

response = requests.post('http://127.0.0.1:5000/test', files=files)

Server logs that it received a request:

got files: ImmutableMultiDict([('dictionary_1', <FileStorage: u'get-pip.py' ('application/json')>)]) 

Apparently, the dictionary_1 was received as FileStorage object.
How to turn the received FileStorage into the Python dictionary?

edited later

The possible duplicate post does not clarify how to send and unpack the Python dictionary object sent via requests(files=list())

This is happening because you're posting files instead of data. This should work:

import flask

app = flask.Flask(__name__)

@app.route('/test', methods=['GET','POST'])
def route(): 
 print('got data: '.format(flask.request.json))
 return Response()

if __name__ == '__main__':
 app.run('0.0.0.0', 5000)

and then send data to your app by

import requests 

dictionary_1 = "file": "url": "https://bootstrap.pypa.io/get-pip.py" 

response = requests.post('http://127.0.0.1:5000/test', json=dictionary_1)

In your example there's no need to post the file unless I'm misunderstanding something

Solution # 1:

from flask import Flask, request, Response
import StringIO, json 

app = Flask(__name__)

@app.route('/test', methods=['GET','POST'])
def route(): 
 print('got files: %s' % request.files)
 for key, file_storage in request.files.items():
 string_io = StringIO.StringIO()
 file_storage.save(string_io)
 data = json.loads(string_io.getvalue())
 print('data: %s type: %s' % (data, type(data)) ) 

 return Response()

if __name__ == '__main__':
 app.run('0.0.0.0', 5000)

Solution # 2:

from flask import Flask, request, Response
import tempfile, json, os, time 

app = Flask(__name__)

@app.route('/test', methods=['GET','POST'])
def route(): 
 print('got files: %s' % request.files)

 for key, _file in request.files.items():
 tmp_filepath = os.path.join(tempfile.mktemp(), str(time.time()))
 if not os.path.exists(os.path.dirname(tmp_filepath)):
 os.makedirs(os.path.dirname(tmp_filepath))

 _file.save(tmp_filepath)

 with open(tmp_filepath) as f:
 json_data = json.loads(f.read())

 print type(json_data), json_data 

 return Response(json_data)

if __name__ == '__main__':
 app.run('0.0.0.0', 5000)