靶标基因

Multi tool use靶标基因是指那些编码疾病蛋白的基因,通过药物对其表达本身的抑制或对其表达产物功能的抑制,有可能达到对疾病的疗效。因此它们往往可能成为新药开发的药物靶标,事先确定靶向特定疾病有关的靶标分子是现代新药开发的基础。
常见的靶标基因包括核内激素受体、各种酶(例如激酶、磷酸酶、ATP合成酶、蛋白酶等、细胞表面受体(如GPCRs、受体骆氨酸激酶、离子通道)、分泌的蛋白质等等。
参考資料
- 新药药物靶标开发技术,2006年版,高等教育出版社, ISBN 7-04018953-4
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